5 research outputs found
Replica Symmetry Breaking Instability in the 2D XY model in a random field
We study the 2D vortex-free XY model in a random field, a model for randomly
pinned flux lines in a plane. We construct controlled RG recursion relations
which allow for replica symmetry breaking (RSB). The fixed point previously
found by Cardy and Ostlund in the glass phase is {\it unstable} to RSB.
The susceptibility associated to infinitesimal RSB perturbation in the
high-temperature phase is found to diverge as
when . This provides analytical evidence that RSB occurs
in finite dimensional models. The physical consequences for the glass phase are
discussed.Comment: 8 pages, REVTeX, LPTENS-94/2
A modular approach toward producing nanotherapeutics targeting the innate immune system
Contains fulltext :
231599.pdf (publisher's version ) (Open Access
In vivo imaging of cerebral glucose metabolism informs on subacute to chronic post-stroke tissue status - A pilot study combining PET and deuterium metabolic imaging.
Recanalization therapy after acute ischemic stroke enables restoration of cerebral perfusion. However, a significant subset of patients has poor outcome, which may be caused by disruption of cerebral energy metabolism. To assess changes in glucose metabolism subacutely and chronically after recanalization, we applied two complementary imaging techniques, fluorodeoxyglucose (FDG) positron emission tomography (PET) and deuterium ((2)H) metabolic imaging (DMI), after 60-minute transient middle cerebral artery occlusion (tMCAO) in C57BL/6 mice. Glucose uptake, measured with FDG PET, was reduced at 48 hours after tMCAO and returned to baseline value after 11 days. DMI revealed effective glucose supply as well as elevated lactate production and reduced glutamate/glutamine synthesis in the lesion area at 48 hours post-tMCAO, of which the extent was dependent on stroke severity. A further decrease in oxidative metabolism was evident after 11 days. Immunohistochemistry revealed significant glial activation in and around the lesion, which may play a role in the observed metabolic profiles. Our findings indicate that imaging (altered) active glucose metabolism in and around reperfused stroke lesions can provide substantial information on (secondary) pathophysiological changes in post-ischemic brain tissue